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Новый алгоритм выявил 870 изменений в альтернативном сплайсинге, характерных для болезни Альцгеймера. Чтобы сопоставить белковые профили двух групп, ученые разработали биоинформатический алгоритм TMTCrunch и применили его к набору данных, включающему более 420 образцов мозга человека. Для этого авторы использовали общедоступные масс-спектрометрические данные, несущие информацию о белковом профиле головного мозга пациентов с…